Protein-coding gene in the species Homo sapiens
APOO |
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Identifiers |
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Aliases | APOO, FAM121B, MIC26, Mic23, My025, Apolipoprotein O, MICOS26 |
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External IDs | OMIM: 300753; MGI: 1915566; HomoloGene: 11475; GeneCards: APOO; OMA:APOO - orthologs |
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Gene location (Human) |
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| Chr. | X chromosome (human)[1] |
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| Band | Xp22.11 | Start | 23,833,353 bp[1] |
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End | 23,907,938 bp[1] |
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Gene location (Mouse) |
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| Chr. | X chromosome (mouse)[2] |
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| Band | X|X C3 | Start | 93,410,723 bp[2] |
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End | 93,460,699 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - decidua
- right ventricle
- myocardium of left ventricle
- prefrontal cortex
- pons
- olfactory zone of nasal mucosa
- lateral nuclear group of thalamus
- triceps brachii muscle
- Brodmann area 9
- anterior cingulate cortex
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| Top expressed in | - quadriceps femoris muscle
- right kidney
- muscle of thigh
- proximal tubule
- muscle tissue
- skeletal muscle tissue
- heart
- secondary oocyte
- primary oocyte
- zygote
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - high-density lipoprotein particle
- extracellular region
- mitochondrial inner membrane
- endoplasmic reticulum membrane
- very-low-density lipoprotein particle
- Golgi membrane
- Golgi apparatus
- membrane
- integral component of membrane
- integral component of mitochondrial inner membrane
- mitochondrion
- endoplasmic reticulum
- low-density lipoprotein particle
- MICOS complex
- extracellular space
- cytosol
| Biological process | - lipid transport
- cristae formation
- transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001199337 NM_001199338 NM_001199339 NM_026673 |
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RefSeq (protein) | | |
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NP_001186266 NP_001186267 NP_001186268 NP_080949 |
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Location (UCSC) | Chr X: 23.83 – 23.91 Mb | Chr X: 93.41 – 93.46 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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ApoO |
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Identifiers |
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Symbol | ApoO |
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Pfam | PF09769 |
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InterPro | IPR019166 |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.[5]
The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.[5]
Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000184831 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079508 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (November 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart". J. Biol. Chem. 281 (47): 36289–302. doi:10.1074/jbc.M510861200. PMID 16956892.
External links
Further reading
- Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
This article incorporates text from the public domain
Pfam and
InterPro: IPR019166