Acetylesterase
Class of enzymes which split acetic esters into alcohols and acetates
acetylesterase | |||||||||
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Identifiers | |||||||||
EC no. | 3.1.1.6 | ||||||||
CAS no. | 9000-82-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In biochemistry, an acetylesterase (EC 3.1.1.6) is a class of enzyme which catalyzes the hydrolysis of acetic esters into an alcohol and acetic acid:
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds (esterases). The systematic name of this enzyme class is acetic-ester acetylhydrolase. Other names in common use include C-esterase (in animal tissues), acetic ester hydrolase, chloroesterase, p-nitrophenyl acetate esterase, and citrus acetylesterase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BS9, 1G66, and 2AXE.
References
- Aldridge WN (January 1953). "Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination". The Biochemical Journal. 53 (1): 110–7. doi:10.1042/bj0530110. PMC 1198110. PMID 13032041.
- Bergmann F, Rimon S (November 1960). "Fractionation of C-esterase from the hog's kidney extract" (PDF). The Biochemical Journal. 77 (2): 209–14. doi:10.1042/bj0770209. PMC 1204974. PMID 16748846.
- Jansen EF, Nutting MD, Balls AK (September 1948). "The reversible inhibition of acetylesterase by diisopropyl fluorophosphate and tetraethyl pyrophosphate" (PDF). The Journal of Biological Chemistry. 175 (2): 975–87. PMID 18880795.
- v
- t
- e
ester hydrolases
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Protein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Protein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
Phosphodiesterase
deoxyribonuclease
and ribonuclease)
3.1.11-16: Exonuclease |
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3.1.21-31: Endonuclease |
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