ARHGEF5 |
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Identifiers |
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Aliases | ARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5 |
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External IDs | OMIM: 600888; MGI: 1858952; HomoloGene: 66300; GeneCards: ARHGEF5; OMA:ARHGEF5 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 7 (human)[1] |
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| Band | 7q35 | Start | 144,355,288 bp[1] |
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End | 144,380,632 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 6 (mouse)[2] |
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| Band | 6|6 B2.1 | Start | 43,242,516 bp[2] |
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End | 43,266,254 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - skin of leg
- skin of abdomen
- mucosa of transverse colon
- left lobe of thyroid gland
- right lobe of thyroid gland
- duodenum
- minor salivary glands
- human kidney
- body of pancreas
- prostate
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| Top expressed in | - skin of external ear
- epithelium of stomach
- duodenum
- lip
- jejunum
- large intestine
- colon
- pyloric antrum
- mucous cell of stomach
- left colon
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - GTP binding
- protein binding
- lipid binding
- guanyl-nucleotide exchange factor activity
| Cellular component | - cytoplasm
- cell projection
- plasma membrane
- nucleoplasm
- cell junction
- podosome
- nucleus
- cell periphery
- cytosol
| Biological process | - intracellular signal transduction
- regulation of actin cytoskeleton organization
- positive regulation of JUN kinase activity
- regulation of GTPase activity
- positive regulation of DNA-binding transcription factor activity
- positive regulation of podosome assembly
- myeloid dendritic cell chemotaxis
- positive regulation of GTPase activity
- positive regulation of protein import
- regulation of ERK1 and ERK2 cascade
- regulation of Rho protein signal transduction
- regulation of cytoskeleton organization
- actin cytoskeleton organization
- positive regulation of stress fiber assembly
- positive regulation of apoptotic process
- regulation of small GTPase mediated signal transduction
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 7: 144.36 – 144.38 Mb | Chr 6: 43.24 – 43.27 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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