Protein-coding gene in the species Homo sapiens
| ANP32D |
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| Identifiers |
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| Aliases | ANP32D, PP32R2, acidic nuclear phosphoprotein 32 family member D |
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| External IDs | OMIM: 606878; GeneCards: ANP32D; OMA:ANP32D - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 12 (human)[1] |
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| | Band | 12q13.11 | Start | 48,472,559 bp[1] |
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| End | 48,473,622 bp[1] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - sural nerve
- embryo
- ganglionic eminence
- urinary bladder
- left adrenal gland
- adrenal cortex
- left adrenal cortex
- right adrenal cortex
- muscle of thigh
- sigmoid colon
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| | | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | | | Cellular component | - nucleus
- perinuclear region of cytoplasm
| | Biological process | - nucleosome assembly
- nucleocytoplasmic transport
- regulation of apoptotic process
- histone exchange
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 12: 48.47 – 48.47 Mb | n/a |
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| PubMed search | [2] | n/a |
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| Wikidata |
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Acidic leucine-rich nuclear phosphoprotein 32 family member D is a protein that in humans is encoded by the ANP32D gene.[3][4][5]
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns.[5]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000139223 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kadkol SS, Brody JR, Pevsner J, Bai J, Pasternack GR (Apr 1999). "Modulation of oncogenic potential by alternative gene use in human prostate cancer". Nat Med. 5 (3): 275–9. doi:10.1038/6488. PMID 10086381. S2CID 24559649.
- ^ Brody JR, Kadkol SS, Mahmoud MA, Rebel JM, Pasternack GR (Aug 1999). "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32". J Biol Chem. 274 (29): 20053–5. doi:10.1074/jbc.274.29.20053. PMID 10400610.
- ^ a b "Entrez Gene: ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D".
Further reading
- Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum. 4 (1): 7–18. doi:10.1080/14734220410019020. PMID 15895553. S2CID 39153579.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kadkol SS, El Naga GA, Brody JR, et al. (2002). "Expression of pp32 gene family members in breast cancer". Breast Cancer Res. Treat. 68 (1): 65–73. doi:10.1023/A:1017919507109. PMID 11678310. S2CID 11915912.
- Bai J, Brody JR, Kadkol SS, Pasternack GR (2001). "Tumor suppression and potentiation by manipulation of pp32 expression". Oncogene. 20 (17): 2153–60. doi:10.1038/sj.onc.1204294. PMID 11360199. S2CID 8755931.
- Kadkol SS, Brody JR, Pevsner J, et al. (1999). "Correction to "Modulation of oncogenic potential by alternative gene use in human prostate cancer"". Nat. Med. 5 (9): 1087. doi:10.1038/12530. PMID 10471270.
External links
