AIM1

Protein-coding gene in the species Homo sapiens
CRYBG1
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

3CW3, 2DAD,%%s2DAD

Identifiers
AliasesCRYBG1, ST4, AIM1, absent in melanoma 1, crystallin beta-gamma domain containing 1
External IDsOMIM: 601797; MGI: 109544; HomoloGene: 18168; GeneCards: CRYBG1; OMA:CRYBG1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CRYBG1
Genomic location for CRYBG1
Band6q21Start106,360,717 bp[1]
End106,572,017 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for CRYBG1
Genomic location for CRYBG1
Band10 B2|10 23.14 cMStart43,826,632 bp[2]
End44,024,849 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of thigh

  • oral cavity

  • gums

  • pancreatic ductal cell

  • gingival epithelium

  • mucosa of pharynx

  • placenta

  • vulva

  • palpebral conjunctiva

  • skin of hip
Top expressed in
  • corneal stroma

  • Ileal epithelium

  • superior surface of tongue

  • esophagus

  • lip

  • skin of back

  • transitional epithelium of urinary bladder

  • skin of external ear

  • lactiferous gland

  • zygote
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • carbohydrate binding
  • molecular function
Cellular component
  • cellular component
Biological process
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

202

11630

Ensembl

ENSG00000112297

ENSMUSG00000019866

UniProt

Q9Y4K1
Q96QW7

n/a

RefSeq (mRNA)

NM_001624
NM_001371242

NM_172393
NM_001368305
NM_001368306

RefSeq (protein)

NP_001615
NP_001358171

n/a

Location (UCSC)Chr 6: 106.36 – 106.57 MbChr 10: 43.83 – 44.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Absent in melanoma 1 protein is a protein that in humans is encoded by the AIM1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112297 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019866 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma". Cancer Research. 51 (20): 5449–53. PMID 1680551.
  6. ^ Rajini B, Graham C, Wistow G, Sharma Y (Apr 2003). "Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)". Biochemistry. 42 (15): 4552–9. doi:10.1021/bi027384l. PMID 12693952.
  7. ^ "Entrez Gene: AIM1 absent in melanoma 1".
  • Human AIM1 genome location and AIM1 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Beta/gamma crystallin domain-containing protein 1 (AIM1)

Further reading

  • Ray ME, Su YA, Meltzer PS, Trent JM (1996). "Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma". Oncogene. 12 (12): 2527–33. PMID 8700511.
  • Ray ME, Wistow G, Su YA, et al. (1997). "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma". Proceedings of the National Academy of Sciences of the United States of America. 94 (7): 3229–34. Bibcode:1997PNAS...94.3229R. doi:10.1073/pnas.94.7.3229. PMC 20351. PMID 9096375.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Aravind P, Rajini B, Sharma Y, Sankaranarayanan R (2006). "Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens". Acta Crystallographica Section F. 62 (Pt 3): 282–4. doi:10.1107/S1744309106005380. PMC 2197174. PMID 16511323.
  • v
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  • 2dad: Solution structure of the fifth crystall domain of the non-lens protein, Absent in melanoma 1
    2dad: Solution structure of the fifth crystall domain of the non-lens protein, Absent in melanoma 1


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