1-Arseno-3-phosphoglycerate

Chemical structure of 1-arseno-3-phosphoglycerate

1-Arseno-3-phosphoglycerate is a compound produced by the enzyme glyceraldehyde 3-phosphate dehydrogenase, present in high concentrations in many organisms, from glyceraldehyde 3-phosphate and arsenate in the glycolysis pathway.[1] The compound is unstable and hydrolyzes spontaneously to 3-phosphoglycerate, bypassing the energy producing step of glycolysis.

Effects on glycolysis

1-Arseno-3-phosphoglycerate can be derived from the glycolytic pathway via the bonding of Arsenate and glyceraldehyde-3-phosphate, which is catalyzed by glyceraldehyde phosphate dehydrogenase (GAPDH).[2] The net production of ATP is zero as a result of the formation of the intermediate, 1-arseno-3-phosphoglycerate, as opposed to the conventional pathway, which produces a net result of two ATP molecules.[3]

Glyceraldehyde − 3 − phosphate + AsO 4 3 − + NAD + → G A P D H NADH + H + + 1 − Arseno − 3 − phosphoglycerate {\displaystyle {\ce {Glyceraldehyde-3-phosphate + AsO4^3- + NAD+ ->[GAPDH] NADH +H+ + 1-Arseno-3-phosphoglycerate}}}

References

  1. ^ Byers LD, She HS, Alayoff A (June 1979). "Interaction of phosphate analogues with glyceraldehyde-3-phosphate dehydrogenase". Biochemistry. 18 (12): 2471–80. doi:10.1021/bi00579a006. PMID 375973.
  2. ^ Chen J, Yoshinaga M, Garbinski LD, Rosen BP (June 2016). "Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance". Molecular Microbiology. 100 (6): 945–53. doi:10.1111/mmi.13371. PMC 4992400. PMID 26991003.
  3. ^ Byers LD (1982-01-01). "Glyceraldehyde-3-phosphate dehydrogenase from yeast". Carbohydrate Metabolism - Part D. Methods in Enzymology. Vol. 89. pp. 326–35. doi:10.1016/S0076-6879(82)89059-9. ISBN 978-0-12-181989-7. PMID 6755173.


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