TREM2

معرفات

أسماء بديلة

TREM2, TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, PLOSL2

معرفات خارجية

الوراثة المندلية البشرية عبر الإنترنت 605086 MGI: MGI:1913150 HomoloGene: 10352 GeneCards: 54209

علم الوجود الجيني
وظائف جزيئية	• scaffold protein binding • lipopolysaccharide binding • lipoteichoic acid binding • peptidoglycan binding • phospholipid binding • signaling receptor activity • amyloid-beta binding • high-density lipoprotein particle binding • lipid binding • low-density lipoprotein particle binding • apolipoprotein binding • apolipoprotein A-I binding • very-low-density lipoprotein particle binding • ‏GO:0032403 protein-containing complex binding • lipoprotein particle binding • protein tyrosine kinase binding • ‏GO:0001948، ‏GO:0016582 ربط بروتيني
مكونات خلوية	• مكون تكاملي للغشاء • غشاء • الفراغ خارج الخلية • غشاء خلوي • integral component of plasma membrane • intrinsic component of plasma membrane
عمليات حيوية	• dendritic cell differentiation • positive regulation of CD40 signaling pathway • positive regulation of calcium-mediated signaling • positive regulation of C-C chemokine receptor CCR7 signaling pathway • phagocytosis, engulfment • detection of peptidoglycan • humoral immune response • cellular response to lipoteichoic acid • positive regulation of protein localization to plasma membrane • regulation of immune response • positive regulation of peptidyl-tyrosine phosphorylation • detection of lipoteichoic acid • مناعة فطرية • detection of lipopolysaccharide • cellular response to peptidoglycan • positive regulation of antigen processing and presentation of peptide antigen via MHC class II • positive regulation of ERK1 and ERK2 cascade • ‏GO:0072468 توصيل الإشارة • osteoclast differentiation • positive regulation of macrophage fusion • positive regulation of amyloid-beta clearance • positive regulation of protein phosphorylation • تنظيم التعبير الجيني • negative regulation of autophagy • ‏GO:1901313 positive regulation of gene expression • positive regulation of mitochondrion organization • regulation of TOR signaling • positive regulation of TOR signaling • regulation of interleukin-6 production • regulation of peptidyl-tyrosine phosphorylation • positive regulation of chemotaxis • regulation of resting membrane potential • positive regulation of astrocyte activation • regulation of macrophage inflammatory protein 1 alpha production • import into cell • regulation of plasma membrane bounded cell projection organization • positive regulation of proteasomal protein catabolic process • positive regulation of inward rectifier potassium channel activity • regulation of intracellular signal transduction • positive regulation of microglial cell activation • negative regulation of autophagic cell death • positive regulation of microglial cell migration • cellular response to amyloid-beta • positive regulation of CAMKK-AMPK signaling cascade • positive regulation of ATP biosynthetic process • apoptotic cell clearance • positive regulation of protein secretion • microglial cell activation • response to ischemia • negative regulation of interleukin-1 beta production • negative regulation of tumor necrosis factor production • positive regulation of interleukin-10 production • negative regulation of apoptotic process • positive regulation of osteoclast differentiation • positive regulation of NIK/NF-kappaB signaling • microglial cell activation involved in immune response • defense response to bacterium • regulation of innate immune response • positive regulation of phagocytosis, engulfment • microglial cell proliferation • amyloid-beta clearance • complement-mediated synapse pruning • neuroinflammatory response • positive regulation of neuroinflammatory response • positive regulation of engulfment of apoptotic cell
المصادر:Amigo / QuickGO

نمط التعبير عن الحمض النووي الريبوزي

المزيد من بيانات التعبير المرجعية

تماثلات متسلسلة

أنواع

الإنسان

الفأر

أنتريه

54209

83433

Ensembl

ENSG00000095970

ENSMUSG00000023992

يونيبروت


Q9NZC2


Q99NH8

RefSeq (رنا مرسال.)


‏NM_018965 NM_001271821، ‏NM_018965


‏NM_031254 NM_001272078، ‏NM_031254

RefSeq (بروتين)


‏NP_061838 NP_001258750، ‏NP_061838


‏NP_112544 NP_001259007، ‏NP_112544

الموقع (UCSC

n/a

Chr 17: 48.65 – 48.66 Mb

بحث ببمد

[1]

[2]

ويكي بيانات

اعرض/عدّل إنسان

اعرض/عدّل فأر

TREM2 (اختصارًا لاسم Triggering receptor expressed on myeloid cells 2) هو بروتين في البشر يُشفر عبر جين TREM2.^[1]^[2]^[3]

المراجع

^ Bouchon A، Dietrich J، Colonna M (مايو 2000). "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes". Journal of Immunology. ج. 164 ع. 10: 4991–5. DOI:10.4049/jimmunol.164.10.4991. PMID:10799849.
^ Paloneva J، Manninen T، Christman G، Hovanes K، Mandelin J، Adolfsson R، Bianchin M، Bird T، Miranda R، Salmaggi A، Tranebjaerg L، Konttinen Y، Peltonen L (سبتمبر 2002). "Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype". American Journal of Human Genetics. ج. 71 ع. 3: 656–62. DOI:10.1086/342259. PMC:379202. PMID:12080485.
^ "Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2". مؤرشف من الأصل في 2010-03-07.

بوابة طب
بوابة علم الأحياء الخلوي والجزيئي

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معرفات كيميائية	قاعدة بيانات التتابع المرجعي (RefSeq RNA): NM_018965

التصنيفات الطبية	دليل الوراثة المندلية عند البشر (OMIM): 605086
المعرفات الخارجية	Ensembl Transcript ID: ENST00000373113 نظام اللغة الطبية الموحدة (UMLS CUI): C1425067